ONGOING RESEARCH PROJECTS
The Camlin Lab’s researches how high-quality eggs capable of supporting embryo development form. We are particularly interested in M-Phase of oocyte meiosis; however, future research plans to extend our meiotic research into mitosis.
Currently funded research projects in the lab:
Future research projects in the Camlin Lab aim to uncover how protein dephosphorylation controls cell cycle progression in meiosis and mitosis.
Currently funded research projects in the lab:
- How does PP1 regulate M-Phase? We have found that PP1 is essential for normal progress through oocyte meiosis. However, the specific cellular pathways and processes PP1 controls are not clear. Research in the lab investigates how PP1 controls accurate oocyte meiosis and how PP1 regulates mitosis/meiosis in yeast.
- PP1 research is hindered by a lack of tools to specifically and temporally control PP1. The lab is focused on developing novel methods to control PP1, to ask more sophisticated questions about PP1's function in M-Phase of mitosis and meiosis.
Future research projects in the Camlin Lab aim to uncover how protein dephosphorylation controls cell cycle progression in meiosis and mitosis.
SELECTED PUBLICATIONS
- Camlin, N. J., et al. (2023). "Oscillations in PP1 activity are essential for accurate progression through mammalian oocyte meiosis." Cell Cycle 22(13): 1614-1636.
- Camlin, N. J. and J. P. Evans (2019). "Auxin-inducible protein degradation as a novel approach for protein depletion and reverse genetic discoveries in mammalian oocytes." Biology of Reproduction 101(4): 704-718.
- Camlin, N. J., et al. (2017). "Kif4 Is Essential for Mouse Oocyte Meiosis." PLOS ONE 12(1): e0170650.
- Camlin, N. J., et al. (2016). "The use of C57Bl/6xCBA F1 hybrid cross as a model for human age‐related oocyte aneuploidy." Molecular Reproduction and Development.